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[DOI] [PubMed] [Google Scholar] 278.Cox A.D., Der C.J

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In vivo and in vitro investigations have determined the anticarcinogenic property of this agent in the case of hepatocarcinoma, which is considered to be a highly aggressive form of cancer, responsible for the large rate of mortality across the globe

This could be of special interest in applications like DNA-PAINT, reducing a potential linkage error

Acknowledgements This work was financially supported by the National Key Research and Development Program of China (2024YFE0201200 [C.C.], 2023YFC3605600 [L.Y.]), the National Natural Science Foundations of China (52173133 [C.C.], 52161145402 [C.C.], 52373148 [C.C.], 82470962 [M.R.B.], U21A20368 [L.Y.]), Sichuan Science and Technology Program (2024NSFSC0672 [M.R.B.], 2023YFS0019 [L.Y.]), the State Key Laboratory of Polymer Materials Engineering (sklpme2021-4-02 [C.C.]), the 135 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYJC21047 [C.C.]), Research Funding from West China School/Hospital of Stomatology Sichuan University (RCDWJS2023-16 [M.R.B.]), Research and Develop Program, West China Hospital of Stomatology Sichuan University (RD-02-202206 [M.R.B.]), and Med-X Innovation Program of Med-X Center for Materials, Sichuan University (MCMGD202301 [L.Y.])

Therefore, this comprehensive review aims to provide an up-to-date critical overview on cereblon-based PROTACs, covering the main aspects related to the chemical synthesis of cereblon ligands derivatives, the chemical ligation of these derivatives to the linkers, and the construction of the final cereblon PROTAC