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Cooperative interaction between AAG and UV-DDB in the removal of modified bases

Whereas, a large number of ROS including superoxide (O 2 ), hydroxyl radical (OH ), perhydroxyl radical (HO 2 ), and other types such as hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), and lipid peroxides (ROOH) [9], is generated as by-products of cellular aerobic metabolism upon different physiological and pathological changes, once exceeding the capacity of the cellular reductase mechanisms, which can result in direct or indirect functional damage to different molecules such as proteins, nucleic acids, and lipids, and eventually lead to cell death [10, 11]

However, resistance mechanisms arise during the treatment with daratumumab, creating the necessity for new therapies

10.1007/s00005-017-0480-8 246 SaxtonR

Glutathione is generally safe for all skin types