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however, that activity was largely reduced when pNK cells were treated with an IGF-1-neutralizing antibody (Fig

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Notably, studies have demonstrated that in diabetic conditions, depletion of the mitochondrial thioredoxin-2 (Trx2)/GSH system in db/db mice disrupts redox homeostasis, resulting in lipid peroxidation of the mitochondrial membrane and impaired activity of respiratory chain complexes

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