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Vitamin A plays a role in multiple systems including the regulation of apoptosis, neurogenesis, immune health, and serotonin systems [19]

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The release and excessive accumulation of collagen fibers caused by overactivated fibroblasts, which are marked with fibroblast activation protein (FAP), lead to pathological changes in the extracellular matrix (ECM) and persistent inflammation, resulting in a vicious cycle of cellular activity and extracellular fibrosis 3,4,5,6,7

Free radicals are highly reactive and can cause oxidative stress, which has been linked to various chronic diseases, such as cardiovascular diseases, certain cancers, and age-related macular degeneration [20]