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Peer review Peer review information Nature Reviews Drug Discovery thanks Timo Mller and the other anonymous reviewer/s for their contribution to the peer review of this manuscript

Collaborations among academia, biotechnology, and pharmaceutical companies strengthen the UKs position as a key player in developing cutting-edge treatments and therapies

Periostin also stimulates keratinocytes to secrete the pruritogen TSLP, which in turn acts on fibroblasts to generate periostin, forming a TSLP- periostin cross-activation loop that sustains chronic itching and maintains Th2 inflammation (60)

Fatigue combined with cold intolerance and brain fog warrants measuring Free T3 rather than TSH alone

The clinical dosage range spans 2.510 mg per subcutaneous injection, titrated over 4 weeks before reaching a maintenance dose of 510 mg, five times weekly

Infection risk Open fissures and excoriated skin create direct entry points for pathogens