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identified the pathogenic gene, Tmem112, in cld/cld mice and re-named it as lipase maturation factor 1 (LMF1) [16]
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OCT2 in particular contributes significantly to accumulation of oxaliplatin, and genetic or pharmacological knockout of OCT2 prevented the development of cold and mechanical hypersensitivity following treatment with oxaliplatin, suggesting that the OCT2 transporter plays a crucial role in oxaliplatin-induced cytotoxicity (Sprowl et al., 2013)
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