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Available from: Maia PAV, Cossich VRA, Salles-Neto JI, Aguiar DP, de Sousa EB

PLGA-based nanoparticles cross the BBB passively by adsorptive-mediated transcytosis (AMT), which is driven by electrostatic interactions between the endothelial surface of the BBB (negatively charged) and PLGA-based nanoparticles (positively charged)

As a whole however the initial and Supplemental DSIPs represent, the first steps toward establishing a grid that can support increasing levels of DERs into the future and ultimately, achieving REV-related goals and objectives"

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It works through different central nervous system pathways and does not directly inhibit COX enzymes in the same way, making it a less disruptive choice for pain management in this context