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In addition to MTF1 to maintain copper homeostasis, mammalian cells express a variety of copper transporter proteins or enzymes, such as copper transporter 1 (CTR1), cytochrome c-oxidase 1 (Cox1), Cox2, Cox11, Cox17, synthesis of cytochrome c oxidase 1 (Sco1), Sco2, superoxide dismutase 1 (SOD1), antioxidant-1 (Atox1), ATPase copper transporting alpha (ATP7A), ATPase copper transporting beta (ATP7B), extracellular superoxide dismutase (ecSOD, SOD3), and lysyl oxidase (LOX)

Even if reclassified, these peptides will remain unapproved, investigational, off-label therapeutics lacking formal Phase III clinical trials, and they will never be available over-the-counter

Research remains in early stages with no human clinical trials currently approved

Nausea (80-90% of Users) Nausea is the most common side effect and the primary reason people abandon MT-II early

[Abstract] Ecotoxicol Environ Saf

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