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Glutathione depletion by hyperphagia-induced obesity

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The chaperone antioxidant-1 (ATOX1) is responsible for transferring Cu to ATP7A and ATP7B in the trans-Golgi network (TGN) and facilitates the synthesis of cuproenzymes such as lysyl oxidase, tyrosinase, and ceruloplasmin 32 (Fig

Kurapati KRV, et al

M.IrvingP

The plasma half-life is estimated at 30-60 minutes, though biological effects on gene expression persist for hours to days