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doi:10.3233/VES-170625 Bazoni JA, Ciquinato DSA, Marquez AS, Costa VSP, Marchiori GM, Marchiori LLM

Since FTH1 and NCOA4 are important proteins related to ferritinophagy, tumor cells of patients with ccRCC may block the autophagy degradation pathway of ferritin in lysosomes through the low expression of NCOA4, downregulate the level of label iron pool in tumor cells, and inhibit the occurrence of ferroptosis to achieve immune evasion of tumor cells

TIGAR, a TP53-induced regulator of glycolysis and apoptosis, plays a crucial role in energy metabolism, autophagy, stem cell differentiation and cell survival (80)

PLoS One 2012;7:e33546

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An even less likely theory suggests dysfunction of methylmalonyl-CoA mutase, which as an important detoxifying enzyme, is highly expressed in most tissues, including the nervous system [40]