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GPX4, a key enzyme in ferroptosis regulation, not only neutralizes polyunsaturated fatty acid hydroperoxides but also mitigates oxidized cholesterol and its esters, highlighting its dual role in ferroptosis and hepatic steatosis ( In vitro studies have confirmed that GPX4 overexpression reduces lipid accumulation in hepatocytes, supporting its protective role against steatosis
[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Bettermann E.L., Hartman T.J., Easley K.A., Ferranti E.P., Jones D.P., Quyyumi A.A., Vaccarino V., Ziegler T.R., Alvarez J.A
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A flavonoid-rich diet is associated with lower risk and improved imaging biomarkers of nonalcoholic fatty liver disease: A prospective cohort study
