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Research has reported that emodin can disturb the peristaltic rhythm of the colon, which can be attributed to cell membrane damage and energy metabolism disorder resulting from inhibition of the activities of Na + -K + -ATPase and Ca 2+ -ATPase and over-activation of IP3 and cAMP in Cajal interstitial cells (Figure 2)
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By contrast, MT2 can lead to diverse effects ranging from mild complaints such as nausea and yawning to potentially serious side effects like increased melanoma risk [13, 21, 22]
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