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Orlando (FL) Minkowitz H, Royal M, Leclerc A, et al

Creatine synthesis is principally regulated by variations in the expression of the renal enzyme that is arginine, glycine aminotransferase, and accessibility of the substrates

But thats low-resolution thinking

HIF-1 has been shown to enhance the expression of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA (113)
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