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Dicoumarol Inhibits Multidrug Resistance Protein 1Mediated Export Processes in Cultured Primary Rat Astrocytes. Neurochemical Research 44: 333346

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The newly determined cryo-EM structures in our work reveal that CCK and gastrin indeed adopt similar linear configurations perpendicular to the bilayer, penetrate into the receptor transmembrane domains (TMDs), and engage CCKR through extensive electrostatic and hydrophobic interactions with residues from all the extracellular loops (ECLs) and TM helices except TM5 (Fig

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Particularly notable is research demonstrating MOTS-cs influence on nuclear gene expression: the peptide has been shown to translocate to the nucleus under stress conditions and bind to AMPK-response elements, directly influencing the transcription of genes involved in stress resistance and metabolic adaptation