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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]

Laboratory best practice calls for working with the compound in a low-humidity environment and minimizing exposure to oxidizing conditions

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Use needles of shorter length (4 mm or the shortest available) and smaller diameter (highest gauge number), and the tip with the lowest penetration force to minimize pain

However, if supplementing for confirmed deficiency, follow-up blood tests may be arranged by your GP to ensure adequacy of treatment

especially the first 2 days after the injection