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Aggregation of these disrupts normal cellular processes, such as protein degradation, resulting in cellular stress and, ultimately, cell death (Tsoi et al., 2023)

Compounds such as alpha-chloroacetamide-based inhibitors achieve this by covalently binding to a cysteine residue in the SAM-binding pocket of NNMT 202

a well-absorbed protector is better than a poorly absorbed energizer, and vice versa

Nikodemus D, Lazic D, Bach M, et al

Iron metabolism also contributes to LPO-induced ferroptosis in melanoma [133]

Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate
