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PMID 8784197

Since mitochondria are essential to our very existence, it is unsurprising that the effects of mitochondrial diseases can be severe, and sometimes lethal, spanning a wide-ranging spectrum of physiological and biochemical symptoms [1,3,4] (see Table 1 for examples)

doi: 10.3389/fnagi.2020.593572

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The peptide molecule must cross the epithelial barrier on its own, driven by the concentration gradient between the high-concentration peptide solution under your tongue and the lower concentration in the capillary blood flowing beneath the epithelium