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Extensive preclinical and clinical research studies have confirmed the positive role that l-carnitine treatment has in male and female fertility [90,91,92,93], pregnancy, premature neonates [94,95,96]

Human studies vary in design, but several themes repeat

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MC4R-mediated nausea is dose-dependent and resolves with receptor desensitization, but forcing through severe nausea increases dropout rates unnecessarily

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