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10.1016/s1542-3565(05)00743-3 85 SalazarC.BarretoM.Adriasola-CarrascoA

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The identified pathway for TMAO formed by dietary PC/choline through the metabolism of gut-flora is a significant additional nutritional contribution to the pathogenesis of CAD, involving PC and choline metabolism, which plays an essential role for the intestinal microbial population as well as in regulating the surface expression rates of macrophage scavenger receptors known to participate in the atherosclerotic process (Fig 1)