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Individuals with this syndrome have an average life expectancy of fewer than 50 years.[226] Cancers have an early onset and occur in up to 43% of these patients.[227] The spectrum of tumors associated with this disorder has primarily been described in the Japanese population and includes an increased incidence of sarcoma, thyroid cancers, and skin cancers.[228] Approximately 20% of the cancers reported in this syndrome are cutaneous, with melanoma and SCC of the skin accounting for 14% and 5%, respectively.[229] A study of 189 individuals with Werner syndrome estimated melanoma risk to be elevated 53-fold in these individuals.[230] SCC was less frequently diagnosed

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