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Research framing remains essential because this catalogue is intended for scientific investigation only

The SASP secreted by senescent chondrocytes increases matrix metalloproteinase (MMP) activity, leading to the breakdown of cartilage and the progression of osteoarthritis.28 Cancer: While cellular senescence serves as a protective mechanism against tumorigenesis by halting the proliferation of damaged or oncogene-expressing cells, the chronic inflammatory environment created by senescent cells can promote cancer progression

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FOXO4-DRI, in contrast, exploits a molecular dependency unique to senescent cells