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Therapeutic implications The biology argues against indiscriminate antioxidant loading. More promising are source- and compartment-targeted strategies (e.g., NOX isoform modulation, mitochondrial quality control, ER stress tuning), buffer re-balancing (GSH/thioredoxin systems), iron management to suppress Fenton chemistry and lifestyle interventions that reshape ROS tone without blunting adaptive signalling

Use of growth factors for the treatment of Parkinson's disease

Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

The anti-inflammatory effects arent a side note

Published human studies (Dhillo et al., JCEM, 2005) used IV bolus doses and observed rapid hormonal responses

Natural killer T cells protect against liver injury, and natural killer T cell-deficient mice exhibit high susceptibility to APAP-induced liver damage 5