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But mitochondria do much more than pump out energy
Eslam, M., Biomarkers of Metabolic (Dysfunction)-associated Fatty Liver Disease: An Update

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Interestingly, a recent report identified that the E3 subunit of PDHC can be nitrosylated (the specific cysteine site was not identified), which inhibits its activity in activated macrophages 9

75 Of the 184 MSI-H ECs, 120 had MLH1 promoter hypermethylation, 25 had a germline mutation associated with LS and 39 had somatic MMR mutations
Doghish AS, El-Husseiny AA, Abdelmaksoud NM, El-Mahdy HA, Elsakka EG, Mageed SSA, et al
