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The GPx mimicking activity of DSePA was studied under in vitro conditions using a GSH-NADH-GR coupled assay

Maximum Responder Rate (20%+ Loss) CagriSema 60% of CagriSema patients achieved at least 20% weight loss in REDEFINE 1, a higher responder rate than tirzepatide's across-trial data, though cross-trial comparison has limitations

[DOI] [PubMed] [Google Scholar] 229.Silva-Herdade A.S., Andolina G., Faggio C., Calado A., Saldanha C

Targeting GSH synthesis/utilization therefore represents a potential means of rendering tumor cells more susceptible to different treatment options such as chemotherapy and radiotherapy

Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA

In: Lee PW, Aizawa H, Gan LL, Prakash C, Zhong D, editors