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Neuroinflammation in ME/CFS was initially suggested by studies showing elevated levels of pro-inflammatory cytokines, and decreased anti-inflammatory cytokines, in cerebrospinal fluid from lumbar punctures in ME/CFS patients [62, 63], and further supported by a positron emission tomography (PET) study [64], which showed increased binding of a radioligand to 18 kDa translocator protein (TSPO) receptor, the expression of which increases when microglia are activated

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The results ranked their contributions in descending order as follows: Moheibacter , L-carnitine, Gaetbulibacter , N,N,N-trimethyllysine, alpha-linolenic acid, betaine, Cnuella , Lacibacter , and MPO

2.4 Electrophysiological assessment of CIPN Behavioral assessment for mechanical allodynia, thermal hyperalgesia and cold allodynia can be subjective in which the researchers often require intensive training and proper blinding during the data collection

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Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome