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SARS-CoV-2 ORF6 protein has also been shown to dysregulate redox homeostasis by decreasing Nrf2 expression, which can enhance viral replication 69

Oncotarget 8 (19), 3169231704

doi:10.4021/jem157w

An outbreak of shingles can sometimes "trigger" other dormant viruses in the body, such as Herpes Simplex (the virus often associated with cold sores), creating a double-hit to the immune system
doi: 10.1039/B307945G 46

Their combined action ensures continuous support against oxidative stress
