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SIM1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus

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MIC stands for methionine, inositol and choline, three nutrients that are vital to breaking down fatty tissue in the body

As obesity rates climb, these molecules promise a scientific approach to stubborn weight

A detailed analysis of the antiobesity action of fenfluramine disclosed that it directly activates hypothalamic POMC neurons through 5-hydroxytryptamine 2C (5-HT2C) receptors that are expressed on a majority of these cells [80]