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Mean diabetes duration ranges from 5.2 2.8 years (Mokhtari et al., 2021) to 15.3 4.1 years (El-Nahas et al., 2020), HbA1c from 7.1% (Essm et al., 2021) to 9.4% (Didangelos et al., 2020), and concomitant medications vary widely (metformin, insulin, SGLT2 inhibitors, pregabalin)

In Using Mathematics to Understand Biological Complexity , 135178 (Springer, 2020)

IFN- decreases ZO-1 protein synthesis, increases internalization of the TJ proteins and rearranges the actin cytoskeleton [17]

The case of levodopa degradation in PD is illustrative: scientists identified a gut bacterial tyrosine decarboxylase that was eating up patients Parkinsons medication, and they found a small-molecule inhibitor that could block this enzyme and thus prevent levodopa loss