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The full-length adiponectin induces depigmentation via AMPK/ CREB-regulated transcription coactivators (CRTCs)/CREB signaling pathway 104 , but the gAd promotes melanogenesis by activation of the AMPK-p38 MAPK-CREB pathway 105

Western blotting Cells were harvested and suspended in Total Lysis Buffer (0.125 M Tris-HCl pH 6.8, 4% SDS and 20% glycerol)

Dng li

This difference was likely attributable to the insufficient inhibition of excessive GJ proteins in hepsin / mice in response to the lower 2APB dose of 1 mg/kg, lending further support to the hypothesis that hepsin may help reduce APAP toxicity by regulating the expression of hepatic GJ proteins

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