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Effects of astaxanthin on blood coagulation, fibrinolysis and platelet aggregation in hyperlipidemic rats

Week 4: right thigh

In fact, first introduced in 1985, the term oxidative stress (today known as oxidative distress) has long linked non-physiological levels of reactive oxygen species (ROS) to oxidation of biomolecules and cellular structures, gene mutations, protein inactivation and aggregation and eventually clinical pathologies (Hanschmann, 2013

doi: 10.7717/peerj.16173 65 JinJCongJLeiSZhangQZhongXSuYet al

doi: 10.1111/j.1469-8137.2010.03582.x 46 HuangS.Van AkenO.SchwarzlnderM.BeltK.MillarA

Initially rapamycin was discovered as a new antifungal agent, and later it was found to show immunosuppressive and anticancer activity by inhibiting the mechanistic target of rapamycin (mTOR) [38]