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Mechanistically, CAT promotes ubiquitination and proteasomal degradation of HIF-1, thereby attenuating osteoclast differentiation and bone resorption (Figure 4)

10.1007/s10103-014-1670-9 80 TestaiL.MartelliA.FloriL.CiceroA

Additionally, SFN combined with 5-aza-2-deoxycytidine and trichostatin A significantly reduced the CpG methylation levels in the NRF2 promoter region and inhibited the protein expression of DNA methyltransferase 1 (DNMT1), thereby promoting NRF2 expression, which may play a preventive role in colon cancer [151]
In addition, the level of immunity and metabolic rate of an individual are genetically related
