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P125 binds to the COP-II component Sec23, and is involved in the organization of COP-II vesicles (which mediate vesicular transport from the endoplasmic reticulum to the Golgi)

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ACAT1, Acetyl-CoA acetyltransferase 1

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However, intranasal and oral administration as well as the discovery of antidepressant activity and lower psychotomimetic effect of isomers and metabolites of KET may foster a wider and longer-term clinical use of KET in the future (Zanos et al., 2016)