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For example, the combination hydrocodone/acetaminophen (e.g

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This mechanism, described as the nosebrain axis, is associated with the anatomical proximity of the olfactory epithelium and CNS structures, and with transport along the pathways of the olfactory and trigeminal nerves

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The partially synthesized xanthone analogs were administered orally to carrageenan-induced paw edema rat models, and their efficacy in reducing inflammation was measured at specific time points