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Sports Med 24:120131, 1997 Huonker M, Halle M, Keul J: Structural and functional adaptations of the cardiovascular system by training

In addition to mediating antibacterial defense, inflammasomes are integral to antiviral immunity by promoting type I interferon production and initiating pyroptosis, a highly inflammatory form of programmed cell death (234, 235)

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Exposure to potentially toxic and environmental contaminants such as heavy metals, smoking and UV/irradiation or abusive drugs such as MDMA and methamphetamine can also produce increased levels of ROS/RNS [41, 42, 44]

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This high cytokine level was coupled with significant increase in Lipid peroxidase (MDA) level in ES group when compared to control group (Fig