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For example, a musculoskeletal model might follow changes in tissue histology and movement patterns, while a gut-focused model could track barrier integrity, local signaling markers, or microbiome shifts

Xiong L, Xiong Z, Hua J, Chen Q, Wang D

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9 However, disease severity is defined by more than just scalp hair, stressed Lal, and additional factors can increase the severity of mild or moderate AA by one level if present