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At an iron concentration of 2.04 mM, 5 0 mM glutarate and 34 0 mM l-2HG accumulated in the supernatant (Figure 4), thus, about 87% of glutarate were converted to l-2HG, while at the standard iron concentration l-2HG and glutarate accumulated to about equimolar concentrations

a , Uptake of [ 13 C 2 , 15 N]-GSH into mitochondria isolated from HEK-293T SLC25A39 knockout cells expressing a vector control, SLC25A39 cDNA, SLC25A10 (DIC, mitochondrial dicarboxylate carrier) or SLC25A11 (OGC, mitochondrial oxoglutarate carrier) cDNA at 5 s and 10 min

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Assessing GSH status is critical for studying oxidative stress mechanisms and downstream effects of oxidative damage

Xu Y, Xiang Z, Alnaggar M, Kouakanou L, Li J, He J, et al

By directly comparing the immune cells of healthy controls with those of ME/CFS and Long COVID patients, the study proved that severe oxidative stress is a shared, defining characteristic of both conditions