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Methods: A PRISMA-guided systematic review was conducted using PubMed and MEDLINE databases with search terms glutathione AND topical AND skin OR dermatology. From 446 articles, only clinical trials on topical glutathione were included, excluding reviews, animal studies, and research on oral or intravenous glutathione

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[DOI] [PubMed] [Google Scholar] 149.Cavalieri E.L., Stack D.E., Devanesan P.D., Todorovic R., Dwivedy I., Higginbotham S., Johansson S.L., Patil K.D., Gross M.L., Gooden J.K., et al

Interestingly, phase separation is an important mechanism for maintaining the formation of protein aggregates, and TREM-1 harbours a wide range of IDRs, which are widely known as critical structures for the formation of diverse protein liquid droplets, supporting the theoretical possibility that the aggregation of TREM-1 on the cell membrane is mediated by phase separation