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Subsequently, experiments showed that LDL binding to the LDL receptor at specific sites on the membranes, called clathrin-coated pits, triggered internalization of the receptor, followed by lysosomal hydrolysis to free the cholesterol from the LDL particle

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For example, TPPU (1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl) urea, an sEH inhibitor) protects wild-type mice from LPS-induced systemic inflammation