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ApoE4 homozygotes are generally at the highest risk for AD, with ApoE2 homozygotes being the most protected (Kim et al., 2009)
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In addition, Zn, along with carnitine, inhibits the cleavage of caspase 3, a key component of apoptosis that is expressed when stimulation by erythropoietin is interrupted (254, 255)

This reaction is catalyzed by glutathione reductase (EC 1.8.1.7)

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