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doi: 10.1016/j.smrv.2012.09.005
For aging people, impaired intestinal function, including mucosal barrier damage and motility disorders, is a significant cause of constipation (27)
Amylin receptors as therapeutic targets in obesity: Emerging peptide-based strategies
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Readouts should triangulate source and compartment: quantify superoxide with DHE-HPLC (particularly informative for NOX2), track H 2 O 2 with compartment-targeted HyPer sensors and couple these to endothelial function tests (e.g., flow-mediated dilation or wire myography), while avoiding nave reliance on raw probe fluorescence (see Small-molecule fluorescent/chemiluminescent probes section) that cannot disambiguate species or sources (Pak et al
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