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Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene

Blood transfusion made the preexisting iron overload worse

BMC Microbiol (2019) 19(1):309

[DOI] [PubMed] [Google Scholar] 113.Tu W., Zhang Q., Liu Y., et al

29 , on the other hand, showed IC 50 values of 34.6 and 31 nM for URAT1, being more potent for URAT1 than the drug used as a standard control, benzbromarone (IC 50 = 47.6 nM)

For this purpose, also nonoral routes of exposure were considered, since the number of oral studies with alkylated furans is very limited and it was expected that such studies might provide more insight into MoAs of the compounds of interest