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Peroxynitrite-mediated nitration of tyrosine residues on proteins orming 3-nitrotyrosine has been documented in active MS plaques and correlates with disease severity and neurodegeneration (Hill et al., 2004

Zheng M, Ruan S, Liu S, et al

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Pivari et al., 2022), improvement of insulin resistance (Thota et al., 2020), inhibition of tumor cell proliferation and metastasis (Zhang Z

RCTs with rigorous lifestyle control [e.g., standardized physical activity protocols] are needed to confirm causal relationships
