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For many years, therefore, glucosamine and chondroitin have been considered possible candidates as disease-modifying drugs

There, Nrf2 binds to antioxidant response elements (ARE) located in the promoter regions of target genes, initiating the transcription of cytoprotective genes and subsequently upregulating the expression of HO-1 and superoxide dismutase 1 (SOD1)

Jia YF, Wininger K, Ho AM, Peyton L, Baker M, Choi DS

The hydroxy and methyl groups of the isohexenyl side chain of the shikonin tail form hydrogen bonds with R188 and Q189, respectively, in the S3 subsite

Energy for osteoclast differentiation generally derives from mitochondrial oxidative metabolism, rather than glycolysis 46,49,50,51

J., Kim, J., & Chae, H