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Docking parameters were as follows: 30 docking trials, the population size of 150, the maximum number of energy evaluation ranges of 25,0000, the maximum number of generations is 27,000, the mutation rate of 0.02, cross-over rate of 0.8, Other docking parameters were set to the softwares default values

Data from scRNA-seq suggested an elevation of iCAFs and a decrease in the proportion of mCAFs in responders (Fig

In many pathological conditions or artificial interventions, increased extracellular glutamate and disrupted xCT structure or function lead to intracellular GSH depletion, thereby inducing ferroptosis (Yadav et al., 2021)

doi: 10.1007/s12035-014-9070-5 177 HunotSBoissireFFaucheuxBBruggBMouatt-PrigentAAgidYet al

1 It has been established that melatonin stimulates GPx in vivo , enhancing GPx activity, during which H 2 O 2 is metabolized to H 2 O, and glutathione (GSH) is oxidized to its disulfide form GSSG (Fig