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Historical Background and Scientific Context Scientific interest in peptide-mediated biological regulation expanded considerably during the late twentieth century as advances in molecular biology enabled researchers to identify increasingly complex signalling systems

DNA damage response factors that persist at sites of damage and nuclear foci, which can be detected cytologically, can also serve as indicators of cellular senescence

36 GLP-1R GLP-1R, a member of the GPCR family, exhibits specific affinity for GLP-1

Published research has quantified this effect directly: at concentrations of 12 M, only 1020% of expected peptide content was recovered from standard borosilicate glass vials and polypropylene tubes after incubation, while low-binding tubes showed significantly better recovery

While the reality of an association between the levels of BDNF in serum and any conditions has been questioned (Zuccato et al., 2011), the results of several meta-analyses suggest that these associations may be real (Brunoni et al., 2008

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