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However, if APAP overdose overwhelms the aforementioned detoxification pathways and depletes GSH to less than 30% of its normal level in the liver, NAPQI accumulates and forms covalent bonds with sulfhydryl groups on cysteine and lysine residues in the mitochondria of the hepatocytes [23,27]

198 MaiuriM

Copper-triggered bioorthogonal cleavage reactions for reversible protein and cell surface modifications

It is not clear whether the -elimination reactions with the busulfan S -conjugates on balance are detoxification or bioactivation events

Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines

Diabetic retinopathy and regulation of mitochondrial glutathione-glutathione peroxidase axis in hyperhomocysteinemia