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Proteomics 16 , 417426 (2016)

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Rosenson RS, Gaudet D, Hegele RA, Ballantyne CM, Nicholls SJ, Lucas KJ, et al

Regarding fatty acid metabolism, besides promoting -oxidation, lipoic acid can inhibit fatty acid synthesis by regulating key enzymes like FASN, lowering hepatic fatty acid levels and reducing lipid accumulation

Using histological and functional assessments, we demonstrated that NAC exerts neuroprotective effects in EAAC1 KO mice without affecting IOP

The following approaches have been identified: The following examples are provided of switches that ensure the safety of the system: inducible caspase-9 suicide genes for emergency cell ablation (128), CRISPR-Cas9-mediated disruption of TCR expression to reduce graft-versus-host disease risk in allogeneic products (129, 130), logic-gated CAR circuits that require sensing of complex, disease-specific signals to trigger activation (131), and transient expression systems employing non-viral mRNA delivery to restrict CAR persistence (132), thereby precisely defining the therapeutic window