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doi: 10.1016/j.jep.2020.112842 21 TongXLZhaoLHLianFMZhouQXiaLZhangJCet al

Higher rates of toxicity were reported in patients receiving ramucirumab treatment ( Tyrosine Kinase Inhibitors Tyrosine kinase inhibitors (TKIs) are small molecules that inhibit the kinase domain of RTKs thus inhibiting receptor activation and downstream signaling ( Sorafenib Sorafenib (Nexavar ) is an oral multikinase inhibitor of VEGFR, PDGF receptor (PDGFR), and Raf (Pitoia and Jerkovich, 2016)

231 Mechanistically, hypoxia-induced HIF1 expression transcriptionally upregulates fatty acid-binding proteins 3 and 7 (FABP3/7), promoting lipid droplet formation via enhancing fatty acid uptake and lipid storage to evade ferroptosis

Included in protocols where oxidative stress management is the primary goal, with the evidence limitation disclosed to patients

The assay monitors the formation of transformed foci and is considered the gold standard for evaluating carcinogenicity as well as a viable alternative to animal testing

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