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10.1530/EC-18-0184 Endocr Connect

It restores hydration, balances electrolytes, and provides targeted treatment with fewer side effects

Allegra L, Cordaro CI, Grassi C

Dinkel, K., Meinck, H

N-acetylcysteine, or NAC, is a supplement that works in two ways: It provides cysteine, which is the rate-limiting amino acid for glutathione production It can also act as a direct antioxidant to scavenge ROS (NO2 and HOX)[ref][ref] The main antioxidant mechanism for NAC is by increasing glutathione levels

In that sense, loss-of-function mutations in KEAP1 gene leading to higher NRF2 activation have been identified in several human adenocarcinoma, with lung cancer being the type where this gene is most mutated 34