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ROS are a major factor of skin aging, involving damage to DNA, the inflammatory response, reduced production of antioxidants, and the generation of matrix metalloproteinases (MMPs) that degrade collagen and elastin in the dermal skin layer, leading to skin wrinkles and reduced elasticity (103)

GSH is also involved in altering proteins, modifying their structure to protect them from oxidative damage

( B ) Quantification of soft agar colony growth in all four conditions expressed as relative to mCherry low

The culture was incubated at 37 C until an OD 600 of 0.40.8, whereupon induction was initiated by the addition of IPTG to a final concentration of 1 mM and the temperature lowered to 18 C

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Regulated necrosis: The expanding network of non-apoptotic cell death pathways